Signs and Symptoms of Indolent Systemic Mastocytosis (ISM)

Medically reviewed by Doru Paul, MD ISM can cause skin changes like itching, flushing, and hives.Credit: Kinga Krzeminska / Getty Images Indolent systemic mastocytosis (ISM) progresses slowly, and symptoms vary depending on the affected organs. Symptoms can include skin changes, digestive problems, severe allergic reactions, neurological changes, and bone pain. Schedule a visit with a […]