10 Things That Can Trigger Indolent Systemic Mastocytosis Symptoms

Medically reviewed by Marla Anderson, MD ISM symptoms like itchy skin can develop from triggers such as insect bites and temperature changes.Credit: Viktoriya Skorikova / Getty Images Indolent systemic mastocytosis (ISM) symptoms appear when mast cells release chemicals such as histamine and tryptase. Symptoms include flushing, itching, hives, stomach pain, diarrhea, brain fog, bone pain, […]