Fact checked by Nick Blackmer
:max_bytes(150000):strip_icc():format(jpeg)/Health-PORTRAITS-PeggyNeal-ffbc39186fe7400fa9f2eeecb401b6dc.png)
Peggy and Neal Dossett first met at a New Year’s Eve party more than 40 years ago.
Peggy: We met, let’s see, in 1985—
Neal: ’84, wasn’t it?
Peggy: ’84, ’85.
Neal: New Year’s Eve of ’84.
Peggy: Yes, it was technically ’84, but almost ’85. And the [ongoing debate] is I say he picked me up, but he says I picked him up. But I’m correct.
After about three and a half years of dating, the Indiana couple married in 1988. Over the decades, the couple enjoyed a full life together, a big highlight being when both retired in 2017—Peggy from being a nurse and Neal from being an engineering technician.
A handful of years after retirement, Peggy started to experience concerning symptoms. It was the start of her journey with chronic spontaneous urticaria (CSU), a skin condition that causes itchy hives and angioedema, which is swelling under the skin, at unpredictable times.
The couple talked with Health about how CSU has affected their day-to-day lives.
The Early Signs of Disease and Flares
Peggy’s first symptoms of CSU began in 2021 or 2022.
Peggy had hives on 85% of her body. The urgent care provider told her to make an appointment with her family medicine doctor. The family medicine doctor wasn’t sure of the diagnosis and recommended Peggy see a dermatologist, allergist, and immunologist. Testing confirmed that Peggy had CSU.
Peggy: A couple times, I had a significant itch that would be gone by the next morning. Mostly, it would happen in the evening. Then one Sunday morning, I woke up with angioedema, and my eyes were swollen shut. I was miserable with that, plus everything itched. I couldn’t see that I had hives, but I could feel that I had hives. So we go to urgent care, and I am one who does not go to urgent care.
After some trial and error, Peggy found a treatment that works for her. Every 28 days, she receives an injection of a biologic medication that provides relief from her hives, itchiness, and inflammation.

Credit: Photo courtesy of Peggy Dossett
Has the treatment helped?
Peggy: Oh, yes, tremendously. I can tell—or Neal can really tell—the week before I’m due [for my treatment] because I will start to have hives. And I’ll have some angioedema. Nothing like what I started with, but I will have some.
Neal, what are some signs that let you know Peggy is starting to have a flare?
Neal: She’s a little bit short. A little more irritable. She’s not irritable usually, but I can kind of sense it; it’s just the tone of her voice and things. It’s like, “Did I do something wrong?” And then, oh, that’s what it is. And I say, “You got a hive?” And then she’ll say, “Yeah.”
Peggy: I don’t like to admit it.
While you don’t like to admit it, would you agree that you have a change in mood with symptoms?
Peggy: I don’t always know it until he says something. But I can tell you I have [a hive] right now on the back of my neck that I’m dying to itch.
Neal itches Peggy’s neck for her.
Peggy: Thank you.
The Harder Days
It takes Peggy two hours to get her monthly medication injection. The week before the treatment is her hardest since the medication effects are wearing off.
Neal, besides knowing that a flare is coming, is there anything else you try to do to help—whether it’s the week before treatment, on treatment days, or during other appointments?
Neal: Once I sense that she’s that way, I don’t irritate her at all. Anything that might upset her, I don’t say anything about; I just go with the flow. On [treatment] days, she’s usually pretty tired, so we try not to do anything on those days.

Credit: Photo courtesy of Peggy Dossett
Peggy: And we don’t work hard on supper or anything that night.
Neal: We don’t do anything that’s going to require a lot of energy because she’s going to be tired, and it’s best for her to just rest that day.
I am assuming, just based on this short time I’ve gotten to know you, that Neal brings a lot of humor.
Peggy: I married him for his entertainment value, that’s what I say.
Neal: Amongst other things.
Has that humor helped you in these years you’ve had CSU?
Peggy: Yes.
Peggy, besides his humor and giving you a little more space during your harder days, is there anything that makes you think, “I'm so glad he’s my partner in all of this”?
Peggy: Just his core. At our wedding all those years ago, [the priest] said that, “Most people see the outward side of Neal that is very gregarious and funny and outgoing, but Peggy sees the marshmallow side of Neal.” I do think that’s very true. So his softness, or his ability to always be there for whatever I need. And I hate that some days I feel that I’m probably short, or whatever word that would be. I don’t like that. That’s not in my DNA—well, it used to not be in my DNA, but apparently it is now.
Neal: Well, it’s not your DNA; it’s the stuff cutting into your DNA that’s making you like that.
Peggy: Yeah… I’m afraid that not everybody could or would be as understanding. Understanding, that’s what he is. He’s a good guy.
Neal: Most of the time.



