Ask a Doctor: Can Too Much Turmeric Really Cause Liver Damage?


The patient on The Pitt experienced jaundice and nausea from turmeric supplements.Credit: Warrick Page/HBO Max
The patient on The Pitt experienced jaundice and nausea from turmeric supplements.
Credit: Warrick Page/HBO Max
  • A storyline on The Pitt reflects real cases of high-dose turmeric supplements causing rare but serious liver injury.
  • The risk is likely due to concentrated doses and added ingredients that boost absorption far beyond what you’d get from the spice.
  • Use caution with supplements and stop immediately if you notice symptoms like jaundice or nausea.

Turmeric is a popular spice and supplement known for its antioxidant properties, which are believed to benefit brain, heart, and metabolic health. But the newest episode of the HBO medical drama The Pitt highlighted a potential risk.

In the show, a 48-year-old woman comes into the ER with jaundice (yellow skin) and nausea, and testing reveals she has inflammation in her liver. It turns out, the patient had been taking five 500-milligram capsules of turmeric a day, and the doctors explain that there have been cases of liver failure in doses of turmeric that large.

Was this just a plotline on a TV show, or can turmeric actually damage your liver? We asked Sohaib Imtiaz, MD, chief medical officer for the People Inc. Health Group, to explain.

Q: Can too much turmeric really cause liver damage?

Yes, turmeric supplements have been definitively linked to liver injury, including cases of acute liver failure.

While turmeric as a culinary spice is generally safe, high-dose turmeric supplements can cause drug-induced liver injury, a form of liver damage caused by medications, herbs, or supplements, which typically develops within one to four months of starting supplementation.

While rare, the scenario described in the show is consistent with documented cases. There have been 10 reported cases of turmeric-associated liver injury between 2004 and 2022, with cases increasing since 2017. Among these patients, five required hospitalization and one died from acute liver failure.

The reaction also appears to be unpredictable, with research suggesting a genetic link—70% of people who developed a turmeric-induced liver injury carried a specific gene that may make them more susceptible. Most patients recover after stopping the supplement, though some require a steroid treatment.

The distinction between eating a spice and taking supplements is critical. Turmeric supplements contain concentrated curcumin—the key anti-inflammatory compound in turmeric—at doses far exceeding culinary use.

What's more, these supplements often contain ingredients that enhance absorption. Many products combine turmeric with piperine (black pepper extract), which increases curcumin absorption 20-fold—potentially contributing to liver damage.

Clinical trials have shown curcumin to be safe at doses up to 8-12 grams per day for short periods, but real-world supplement use has revealed a liver damage risk that wasn't apparent in the controlled trials.

The bottom line: Patients considering turmeric supplements should understand that "natural" doesn't mean "safe." Supplements are poorly regulated with inconsistent labeling, and any new-onset fatigue, jaundice, or abdominal symptoms warrant immediate discontinuation and medical evaluation.



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Elasticsearch Aggregations – Table of Content

Characteristics

  • It can be formed together to manufacture complex sum up of information. 
  • It tends to be considered as a single unit-of-work that makes analytic data over a bunch of archives which are accessible in elasticsearch. 
  • It is fundamentally based on the building blocks. 
  • Aggregation functions are the same as GROUP BY COUNT and SQL AVERAGE functions.
  • Utilizing aggregation in elasticsearch, can perform GROUP BY aggregation on any numeric field, yet we should type keywords or there must be fielddata = valid for text fields.

Four categories of Aggregations 

Bucket aggregations

Bucketing is a group of aggregations, which is liable for building buckets. It doesn’t figure metrics over the fields like metric collection. Each pail is related with a key and a report. It is utilized to gather or make information buckets. These information buckets can be made dependent on the current fields, ranges, and altered filters, and so on.

Metric aggregations

These aggregations help in processing matrices from the field’s estimations of the collected reports and at some point a few values can be produced from contents. Numeric matrices can either be single-valued like average aggregation or multi-valued like stats.

Pipeline aggregations

It takes contributions from the yield of different aggregations. Pipeline aggregations are liable for assembling the yield of different aggregations.

Matrix aggregations

Matrix collection is an aggregation that works on different fields. It deals with more than one field and creates a matrix result out of the values, that is extricated from the solicitation record fields. It doesn’t uphold scripting. 

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Types of Aggregations

1. Filter Aggregation

The filter aggregation assists with separating the archives in a solitary bucket. Its fundamental reason for existing is to give the best outcomes to its clients by sifting the archive. We should take a guide to channel the reports dependent on “fees” and “Admission year”. It will restore archives that coordinate with the conditions determined in the query. You can filter the report utilizing any field you need.

POST student/ _search/  

{  

       "query": {    

            "bool": {  

                "filter": [  

                     { "term": { "fees": "22900" } },  

                     { "term": { "Admission year": "2019" } },  

                 ]  

           }  

    }  

}  

Response

{   

"took": 5,  

"timed_out": false,  

"_shards": {  

"total": 1,  

"successful": 1,  

"skipped": 0,  

"failed": 0  

},  

"hits": {  

                   "total": {  

  "value": 1,  

  "relation": "eq"  

           },  

"max_score": 0,  

"hits": [ ]  

{  

         "index": "student",  

          "type": "_doc",  

         "id": "02",  

         "score": 1,  

         "_source": {  

  "name ": "Jose Fernandez",  

 "dob": "07/Aug/1996",  

 "course": "Bcom (H)",  

 "Admission year": "2019",  

  "email": "jassf@gmail.com",  

 "street": "4225 Ersel Street",   

  "state": "Texas",   

 "country": "United States",   

  "zip": "76011",  

  "fees": "22900"  

                   }  

             }  

         ]  

      }  

}  

2. Terms Aggregation

The terms aggregation is liable for producing buckets by the field esteems. By choosing a field (like name, admission year, and so forth), it creates the buckets. Determine the aggregation name in query while making an inquiry. Execute the accompanying code to look through the values assembled by admission year field:

POST student/ _search/  

{  

   "size": 0,    

    "aggs": {    

       "group_by_Admission year": {  

               "terms" : {   

                    "field": "Admission year.keyword"  

                }  

          }  

    }  

}  

By executing the above code, it  will be returned as a group by admission year. The output is as follows.

Output

{   

"took": 179,  

"timed_out": false,  

"_shards": {  

"total": 1,  

"successful": 1,  

"skipped": 0,  

"failed": 0  

},  

"hits": {  

                   "total": {  

 "value": 3,  

 "relation": "eq"  

          },  

"max_score": null,  

"hits": [ ]  

},  

  "aggregations":  {  

         "group_by_Addmission year": {  

             "student1",  

             "doc_count_error_upper_bound": 0,  

             "sum_other_doc_count": 0,  

              "buckets": [  

              {  

      "key ": "2019",  

      "doc_count": 2   

 },  

 {  

      "key": "2018",  

      "doc_count": 1  

}  

                  ]  

          }  

     }  

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3. Nested Aggregation

A nested aggregation permits you to assemble a field with nested reports, a field that has numerous sub-fields.A unique single bucket aggregation that empowers accumulating nested archives. For instance, let’s state we have a list of products, and every item holds the list of resellers, each having its own cost for the item.  Resellers is an array that holds nested documents. The mapping could resemble:

PUT /products

{

  "mappings": {

    "properties": {

      "resellers": { 

        "type": "nested",

        "properties": {

          "reseller": { "type": "text" },

          "price": { "type": "double" }

        }

      }

    }

  }

}

The following request adds a product with two resellers:

PUT /products/_doc/0

{

  "name": "LED TV", 

  "resellers": [

    {

      "reseller": "companyA",

      "price": 350

    },

    {

      "reseller": "companyB",

      "price": 500

    }

  ]

}

The following request returns the minimum price a product can be purchased for:

GET /products/_search

{

  "query": {

    "match": { "name": "led tv" }

  },

  "aggs": {

    "resellers": {

      "nested": {

        "path": "resellers"

      },

      "aggs": {

        "min_price": { "min": { "field": "resellers.price" } }

      }

    }

  }

}

Output

{

  ...

  "aggregations": {

    "resellers": {

      "doc_count": 2,

      "min_price": {

        "value": 350

      }

    }

  }

 }

4. Cardinality Aggregation

This aggregation gives the tally of distinct values in a specific field. It helps to find a unique value for a field. 

POST /schools/_search?size=0

{

   "aggs":{

      "distinct_name_count":{"cardinality":{"field":"fees"}}

   }

}

On running the above code, we get the following result,

Output

{

   "took" : 2,

   "timed_out" : false,

   "_shards" : {

      "total" : 1,

      "successful" : 1,

      "skipped" : 0,

      "failed" : 0

   },

   "hits" : {

      "total" : {

         "value" : 2,

         "relation" : "eq"

      },

      "max_score" : null,

      "hits" : [ ]

   },

   "aggregations" : {

      "distinct_name_count" : {

         "value" : 2

      }

   }

}

The value of cardinality is 2 because there are two distinct values in fees.

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5. Extended Stats Aggregation

This aggregation produces all the statistics about a particular mathematical field in collected documents. 

POST /schools/_search?size=0

{

   "aggs" : {

      "fees_stats" : { "extended_stats" : { "field" : "fees" } }

   }

}

On running the above code, we get the following result,

Output

{

   "took" : 8,

   "timed_out" : false,

   "_shards" : {

      "total" : 1,

      "successful" : 1,

      "skipped" : 0,

      "failed" : 0

   },

   "hits" : {

      "total" : {

         "value" : 2,

         "relation" : "eq"

      },

      "max_score" : null,

      "hits" : [ ]

   },

   "aggregations" : {

      "fees_stats" : {

         "count" : 2,

         "min" : 2200.0,

         "max" : 3500.0,

         "avg" : 2850.0,

         "sum" : 5700.0,

         "sum_of_squares" : 1.709E7,

         "variance" : 422500.0,

         "std_deviation" : 650.0,

         "std_deviation_bounds" : {

            "upper" : 4150.0,

            "lower" : 1550.0

         }

      }

   }

}

6. Stats Aggregation

A multi-value metrics aggregation that figures statistics over numeric values removed from the aggregated reports. It is a multi-value numeric matrix aggregation that helps to create sum, avg, max, min, and count in a single shot. The query structure is the same as the other aggregation

POST /schools/_search?size=0

{

   "aggs" : {

      "grades_stats" : { "stats" : { "field" : "fees" } }

   }

}

On running the above code, we get the following result,

Output

{

   "took" : 2,

   "timed_out" : false,

   "_shards" : {

      "total" : 1,

      "successful" : 1,

      "skipped" : 0,

      "failed" : 0

   },

   "hits" : {

      "total" : {

         "value" : 2,

         "relation" : "eq"

      },

      "max_score" : null,

      "hits" : [ ]

   },

   "aggregations" : {

      "grades_stats" : {

         "count" : 2,

         "min" : 2200.0,

         "max" : 3500.0,

         "avg" : 2850.0,

         "sum" : 5700.0

      }

   }

}

Avg Aggregation

This collection is utilized to get the avg of any numeric field present in the collected records. 

POST /schools/_search

{

   "aggs":{

      "avg_fees":{"avg":{"field":"fees"}}

   }

}

On running the above code, we get the following result −

Output

{

   "took" : 41,

   "timed_out" : false,

   "_shards" : {

      "total" : 1,

      "successful" : 1,

      "skipped" : 0,

      "failed" : 0

   },

   "hits" : {

      "total" : {

         "value" : 2,

         "relation" : "eq"

      },

      "max_score" : 1.0,

      "hits" : [

         {

            "_index" : "schools",

            "_type" : "school",

            "_id" : "5",

            "_score" : 1.0,

            "_source" : {

               "name" : "Central School",

               "description" : "CBSE Affiliation",

               "street" : "Nagan",

               "city" : "paprola",

               "state" : "HP",

               "zip" : "176115",

               "location" : [

                  31.8955385,

                  76.8380405

               ],

            "fees" : 2200,

            "tags" : [

               "Senior Secondary",

               "beautiful campus"

            ],

            "rating" : "3.3"

         }

      },

      {

         "_index" : "schools",

         "_type" : "school",

         "_id" : "4",

         "_score" : 1.0,

         "_source" : {

            "name" : "City Best School",

            "description" : "ICSE",

            "street" : "West End",

            "city" : "Meerut",

            "state" : "UP",

            "zip" : "250002",

            "location" : [

               28.9926174,

               77.692485

            ],

            "fees" : 3500,

            "tags" : [

               "fully computerized"

            ],

            "rating" : "4.5"

         }

      }

   ]

 },

   "aggregations" : {

      "avg_fees" : {

         "value" : 2850.0

      }

   }

}

Max Aggregation

This aggregation finds the maximum value of a particular numeric field in collected archives. 

POST /schools/_search?size=0

{

   "aggs" : {

   "max_fees" : { "max" : { "field" : "fees" } }

   }

}

On running the above code, we get the following result −

Output

{

   "took" : 16,

   "timed_out" : false,

   "_shards" : {

      "total" : 1,

      "successful" : 1,

      "skipped" : 0,

      "failed" : 0

   },

  "hits" : {

      "total" : {

         "value" : 2,

         "relation" : "eq"

      },

      "max_score" : null,

      "hits" : [ ]

   },

   "aggregations" : {

      "max_fees" : {

         "value" : 3500.0

      }

   }

}

Min Aggregation

This aggregation finds the maximum value of a particular numeric field in collected archives. 

POST /schools/_search?size=0

{

   "aggs" : {

      "min_fees" : { "min" : { "field" : "fees" } }

   }

}

On running the above code, we get the following result −

Output

{

   "took" : 2,

   "timed_out" : false,

   "_shards" : {

      "total" : 1,

      "successful" : 1,

      "skipped" : 0,

      "failed" : 0

   },

   "hits" : {

      "total" : {

         "value" : 2,

         "relation" : "eq"

      },

      "max_score" : null,

      "hits" : [ ]

   },

  "aggregations" : {

      "min_fees" : {

         "value" : 2200.0

      }

   }

}

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Sum Aggregation

This aggregation finds the maximum value of a particular numeric field in collected archives.

POST /schools/_search?size=0

{

   "aggs" : {

      "total_fees" : { "sum" : { "field" : "fees" } }

   }

}

On running the above code, we get the following result −

Output

{

   "took" : 8,

   "timed_out" : false,

   "_shards" : {

      "total" : 1,

      "successful" : 1,

      "skipped" : 0,

      "failed" : 0

   },

   "hits" : {

      "total" : {

         "value" : 2,

         "relation" : "eq"

      },

      "max_score" : null,

      "hits" : [ ]

   },

   "aggregations" : {

      "total_fees" : {

         "value" : 5700.0

      }

   }

}

7. Aggregation Metadata

You can add some information about the aggregation at the hour of solicitation by utilizing meta tag and can get that accordingly.

POST /schools/_search?size=0

{

   "aggs" : {

      "min_fees" : { "avg" : { "field" : "fees" } ,

         "meta" :{

            "dsc" :"Lowest Fees This Year"

         }

      }

   }

}

On running the above code, we get the following result −

Output

{

   "took" : 0,

   "timed_out" : false,

   "_shards" : {

      "total" : 1,

      "successful" : 1,

      "skipped" : 0,

      "failed" : 0

   },

   "hits" : {

      "total" : {

         "value" : 2,

         "relation" : "eq"

      },

      "max_score" : null,

      "hits" : [ ]

   },

   "aggregations" : {

      "min_fees" : {

         "meta" : {

            "dsc" : "Lowest Fees This Year"

         },

         "value" : 2850.0

      }

   }

}

Conclusion

The different types of aggregations have their own purpose and functions. We have discussed it in detail about it using the coding examples. There exists metrics aggregations that are used in particular cases such as geo bounds aggregation and geo centroid aggregation to get the understanding of geo location. You could understand the concept of aggregation through the examples provided.

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