We Asked a Pharmacist Why Multivitamins Make Some People Feel Nauseous



Medically reviewed by Patricia Mikula, PharmD

Credit: Ariawan Armoko / Getty Images
Credit: Ariawan Armoko / Getty Images
  • Multivitamins often contain concentrated forms of some ingredients like iron, zinc, magnesium, and ​​vitamin C, which can irritate the linings of the stomach, and make you feel nauseous.
  • Taking multivitamins, especially more than the required dose, can make your nausea worse.
  • Taking multivitamins with food can reduce the risk of nausea.

You are not alone if you have ever taken a multivitamin and felt nauseous. Multivitamins can irritate the stomach lining and cause digestive side effects, especially when you take them on an empty stomach.

Understanding why this happens can help you prevent side effects so that you can take multivitamins comfortably and fill nutritional gaps.

Why Do Multivitamins Make You Nauseous?

Multivitamins can cause nausea due to their ingredients, which may be harsh on the stomach.

Multivitamins often contain concentrated forms of ingredients such as iron, zinc, magnesium, and vitamin C, which can increase stomach acid and irritate the stomach lining, especially when there is no food to act as a buffer.

For example, high doses of iron have been found to increase gut inflammation and alter gut bacteria, increasing the risk of nausea and other gastrointestinal side effects such as cramps, vomiting, diarrhea, and constipation.

Similarly, ascorbic acid, the most common form of vitamin C used in supplements, has very high acidity and may trigger nausea when taken in doses higher than recommended.

​Taking multivitamins, especially more than the required dose, can make your nausea worse, especially if you have a sensitive stomach.

Studies have found that exceeding the recommended doses of iron (more than 45 milligrams (mg) per day), zinc (40 mg per day), or vitamin C (2000 mg per day; sometimes 400mg, depending on age) can cause nausea.

Which Ingredients Are More Likely To Trigger Nausea?

Active and inactive ingredients in multivitamins can trigger nausea.

The most common vitamins and minerals in multivitamins known to cause nausea and vomiting, when taken in high doses, include:​

  • Oral iron
  • Zinc
  • Vitamin C
  • Magnesium
  • Vitamin D
  • Calcium

Other inactive ingredients in multivitamins, such as binders, fillers, and sweeteners, can also trigger nausea. Some examples include:

  • Lactose
  • Mannitol
  • Sodium Benzoate
  • Artificial sweeteners

Multivitamins containing botanicals such as elderberry, cranberry, fenugreek, and echinacea can also irritate the stomach in some people, triggering nausea.

Why Is It Worse To Take Them on an Empty Stomach?

While some vitamins and minerals are better absorbed on an empty stomach, taking multivitamins without food can worsen nausea.

Food often acts as a buffer, or coat, on the stomach, preventing supplements from irritating the stomach lining. Supplements with very high acidity, like vitamin C (ascorbic acid), will worsen nausea if taken without any food.

Taking multivitamins containing fat-soluble vitamins (A, D, E, K) without food, particularly with fat-rich foods like avocados or olive oil, can reduce their absorption and cause stomach discomfort, such as nausea.​

How Can You Prevent Nausea?

Here are some steps you can take to prevent nausea when taking multivitamins:​

  • Choose concentrations below the recommended daily amounts: Avoid taking multivitamins with very high doses of individual supplements. If you are unsure of the recommended upper limit, talk to your pharmacist or healthcare provider.
  • Take with food: Taking multivitamins with food can reduce the risk of nausea. Even a simple cracker can help.
  • Choose multivitamins with fewer inactive ingredients: Take multivitamins with fewer artificial sweeteners or flavors.
  • Consider taking supplements at different times of the day: If you notice taking multivitamins in the morning makes you nauseous, try taking them in the evening.
  • Try a different multivitamin: Multivitamins are not all made the same. Some manufacturers may use ingredients that are less upsetting to your stomach. Ask your pharmacist for help choosing a brand that is less likely to cause nausea for you.

Dietary supplements are minimally regulated by the FDA and may or may not be suitable for you. The effects of supplements vary from person to person and depend on many variables, including type, dosage, frequency of use, and interactions with current medications. Please speak with your healthcare provider or pharmacist before starting any supplements.



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Misinformation about sunscreen makes up a small portion of TikTok videos about the subject, but those posts are disproportionately popular and widely shared, a new study finds.

Wellness topics are commonly affected by misinformation spread online. That includes content related to sunscreen — a crucial tool in preventing skin cancer. A new peer-reviewed study conducted by researchers at the University of Alberta found that misinformation on TikTok receives higher audience engagement compared to pro-sunscreen content. 

The study looked at 971 of the most-viewed TikTok videos about sunscreen and found that the most-viewed videos had anti-sunscreen messaging. These videos only made up a small fraction of content found on TikTok (6%), compared to pro-sunscreen videos (86.8%). And only 1.5% of the posts the researchers reviewed claimed sunscreen caused harm.

Although there are fewer anti-sunscreen videos, these attract the most attention because the messaging is more provocative, the researchers said. Public health officials have been concerned about the anti-sunscreen movement that claims, falsely, that sunscreen is harmful or prevents the health benefits of sun exposure. Among the myths these messages spread include that sunscreen causes cancer, it blocks the absorption of Vitamin D and that it’s toxic to humans. The popularity of this content on TikTok could influence viewers, particularly younger ones, to avoid it altogether. 

It’s not surprising that many Americans turn to social media for health advice. A Pew Research Center survey released in April found 36% of Americans reported getting health information at least sometimes from social media. (And 22% said they got health information from AI chatbots.) Wellness influencers know how to make particularly engaging content, which makes it easier for others to believe the message they’re sharing — even if it’s false or misleading. 

Experts attribute the willingness of Americans to believe sunscreen misinformation to a wide range of factors.

“I think sunscreen skepticism grew out of a few overlapping movements: clean beauty, distrust of institutions, fear of synthetic ingredients and a general wellness culture that tends to frame ‘natural’ as automatically safer,” Dr. Melanie Palm, a board-certified dermatologist and cosmetic surgeon at Art of Skin MD, tells CNET. Sensationalized messages spread easily on social media because they feed on real human fears. 

Although there’s relatively more pro-sunscreen TikTok content, experts believe the messaging for this has been short-sighted as well. The study found that the majority of sunscreen content promoted on TikTok was mainly centered around its beauty benefits, versus only 6% mentioning cancer risk reduction.

“For many people, especially younger people, photoaging feels more relevant than cancer prevention,” Palm says. Not that sun protection lacks beauty benefits. ”I don’t think it’s wrong to talk about the beauty benefits of sunscreen because sunscreen does help prevent brown spots, uneven tone, collagen breakdown, and premature aging,” Palm says. 

Since sunscreen content has leaned more towards the beauty angle, its skin cancer prevention messaging has been downplayed. “Dermatologists and brands need to say it [sunscreen can prevent skin cancer] more clearly, and we need to say it in plain language,” Palm says. The problem is that often the facts on social media sound like a lecture. Palm believes experts can work on explaining themselves better without diluting the science and being less dismissive if a patient is worried about sunscreen use.

“We can say, ‘I understand why that sounds concerning — here is what the evidence actually shows, and here are options if you prefer mineral sunscreen, tinted sunscreen, fragrance-free formulas or newer filters,’” Palm suggests. 

Palm recommends experts active on social media focus on shorter videos, simpler analogies and real-life examples of sun damage. That’s just one piece of the equation. Sunscreen manufacturers marketing their products on social media often use fear-based language. Palm recommends that they focus on educating the public instead. This includes explaining common terms such as “broad-spectrum” or why it’s important to reapply sunscreen. “Show sunscreens on different skin tones, because if a product leaves a white cast or pills under makeup, people are not going to wear it daily,” Palm says. 

With research showing that more people are receiving their news from social media, it’s prime time for experts to appear as relatable as possible when sharing content on social platforms. Sunscreen brands can aim to educate younger people on the importance of skin protection and still speak about its beauty benefits. Even if you’re sharing the truth on social media, the way you get that message across is just as important if you want to reach a greater audience. 





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